Drug eruption
☆ Katika matokeo ya 2022 ya Stiftung Warentest kutoka Ujerumani, kuridhika kwa watumiaji na ModelDerm kulikuwa chini kidogo kuliko na mashauriano ya matibabu ya simu yanayolipishwa.
Drug eruption ina sifa ya kuathiri mwili mzima.
References
Athari za ngozi zinazosababishwa na dawa, zinazojulikana kama milipuko ya dawa, wakati mwingine zinaweza kuwa kali. Matendo haya makali, yanayoitwa severe cutaneous adverse drug reactions (SCARs) , yanachukuliwa kuwa ya kutishia maisha. Zinajumuisha masharti kama Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Ingawa SCARs ni nadra, karibu 2% ya wagonjwa wanaolazwa hospitalini wanazipata.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Mwanamke mwenye umri wa miaka 31 alitembelea idara ya ngozi akiwa na sehemu nyekundu isiyo na maumivu juu ya mguu wake wa kulia. Alichukua dozi moja ya doxycycline (miligramu 100) siku moja kabla, kufuatia matibabu ya laser ya picosecond kwa makovu ya chunusi. Mwaka jana, alipata tatizo kama hilo katika sehemu moja baada ya kuchukua kipimo sawa cha matibabu ya baada ya laser ya doxycycline. Hana historia muhimu ya matibabu na hana dalili zingine, kama homa, ndani au mwili wake wote.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) na toxic epidermal necrolysis (TEN) ni aina mbili za athari mbaya ya ngozi, tofauti na hali nyingine za ngozi kama vile erithema multiforme kuu na ugonjwa wa ngozi wa staphylococcal scalded, pamoja na athari za madawa ya kulevya. SJS/TEN ni mmenyuko nadra na kali unaosababisha uharibifu mkubwa wa ngozi na utando wa mucous, mara nyingi kwa dalili za utaratibu. Katika zaidi ya 80% ya kesi, dawa ni sababu.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Mlipuko wa madawa ya kulevya hugunduliwa hasa kutokana na historia ya matibabu na uchunguzi wa kliniki. Biopsy ya ngozi, vipimo vya damu au vipimo vya kinga pia vinaweza kuwa muhimu.
Mifano ya dawa za kawaida zinazosababisha mlipuko huo ni viua vijasumu na dawa zingine za kuzuia vijidudu, dawa za salfa, dawa zisizo za steroidal za kuzuia uchochezi (NSAIDs), dawa za kidini kwa magonjwa mabaya, anticonvulsants na dawa za kisaikolojia.
○ Uchunguzi na Tiba
Ikiwa una homa (kuongezeka kwa joto la mwili), unapaswa kutafuta matibabu haraka iwezekanavyo. Dawa inayoshukiwa inapaswa kukomeshwa (kwa mfano, antibiotics, dawa zisizo za steroidal za kuzuia uchochezi). Kabla ya kutembelea hospitali, antihistamines ya mdomo kama vile cetirizine au loratadine inaweza kusaidia kwa kuwasha na upele.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Jaribio la damu (CBC, LFT, hesabu ya eosinophil)
Steroids ya mdomo na antihistamines kwa maagizo ya daktari